2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   2637-2644

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simvastatin Loaded Polycaprolactone-collagen Scaffolds for the treatment of Diabetic Foot Ulcer



Address:   Kalaivani C1, Gowthamarajan Kuppusamy2, Saikamal3, Veera Venkata Satyanarayana Reddy Karri3
1Department of Pharmaceutics, JSS College of Pharmacy, Ooty.
2Professor and Head Department of Pharmaceutics, JSS College of Pharmacy, Ooty.
3Department of Pharmaceutics, JSS College of Pharmacy, Ooty.
4Veera Venkata Satyanarayana Reddy Karri, Assistant Professor, JSS College of Pharmacy, Ooty.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00441.4

ABSTRACT:
Scaffolds are the adaptable tools for the treatment of diabetic wounds, In this study, Simvastatin was loaded in polycaprolactone-collagen scaffolds for the treatment of diabetic foot ulcer using the freeze-drying technique. Eventually scaffolds characterization were observed in terms of Scanning Electron Microscopy, Differential scanning calorimetry (DSC), Porosity, Water absorption test, Matrix degradation, In vitro drug release studies, cell proliferation assay, cytotoxicity assay. Scaffolds prepared with polycaprolactone and collagen-polymer showed the homogeneous distribution with high porosity, extended biodegradation rate, high water uptake. All the scaffold formulation showed the sustained drug release and then a plateau. The cross-Linked scaffold has significant slower release in comparison to non-crosslinked scaffold, this is because of cross-linking of the scaffolds where the chemical and mechanical bonding is high compared to non-crosslinked scaffold, Non-crosslinked, showed 85.34% of drug release by this it can be concluded that non cross-linked scaffolds showed the prolonged release, In the cell proliferation assay after 72 h, the cell growth was found to be greater when we compared with placebo and control due to the presence of drug, which explains that the cells are in logarithmic phase. Noncross linked scaffold has shown an increase in cell growth by 28% from its initial value. In Differential Scanning Calorimetry (DSC) shows that there is no change in the peaks by that we can confirm that all the excipients are compatible to each other The obtained results imply that the investigated scaffold is a potential candidate for skin regeneration application because the present study states that simvastatin is having all the properties to treat the Diabetic Foot Ulcer(DFU) without producing the resistance.
KEYWORDS:
Simvastatin, polycaprolactone, collagen, composite scaffolds, diabetic wounds.
Cite:
Kalaivani C, Gowthamarajan Kuppusamy, Saikamal, Veera Venkata Satyanarayana Reddy Karri. Simvastatin Loaded Polycaprolactone-collagen Scaffolds for the treatment of Diabetic Foot Ulcer. Research J. Pharm. and Tech. 2019; 12(6): 2637-2644.
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