2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   2776-2780

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Maltodextrin Based Doxorubicin HCl Proniosomes

Address:   Srikanth1*, Anand Kumar Y2, Mallikarjuna Setty C3
1Research Scholar at JNTU Hyderabad and V. L. College of Pharmacy, Raichur, India.
2Department of Pharmaceutics, V. L. College of Pharmacy, Raichur, India.
3Department of Pharmaceutics, Oxford College of Pharmacy, Bengaluru, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00466.9

Aim of the present research work is to prepare and evaluate maltodextrin based proniosomes loaded with doxorubicin HCl. Proniosomes were prepared by slurry method using molar ratios of nonionic surfactant with cholesterol and keeping drug, maltodextrin and DCP constant. The niosomes were prepared by simple hydration and further evaluated for entrapment efficiency, particle size and shape analysis by optical microscopy, in vitro drug release study, kinetic data analysis and model fitting. Stability study by ICH guides lines. The study revels more stable when stored at 40C. The formulation FD3, which showed entrapment efficiency of 84.88 ± 0.14 and in vitro release over the period of 36h 95.19± 0.20, was found to be best formulation is span 60. The niosomes shows the Korsemayer Peppas exponential n<0.84 indicate the release mechanism was non Ficknian (anomalous transport) i.e. drug released by erosion followed by diffusion mechanism.
Doxorubicin HCl, Proniosomes, Niosomes, Surfactants, Cholesterol.
Srikanth, Anand Kumar Y, Mallikarjuna Setty C. Formulation and Evaluation of Maltodextrin Based Doxorubicin HCl Proniosomes. Research J. Pharm. and Tech. 2019; 12(6): 2776-2780.
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