2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   2742-2747

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using , UV Spectrophotometric Method



Address:   Chinmoy Kumar1, Manish Kumar1*, Vipin Saini2, Shailendra Bhatt1, A. Pandurangan1, Anuj Malik1, Preeti Pal1, Laxmi Narayan Shetty3
1M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana
2M M University, Solan, Himachal Pradesh.
3Reginal Drugs Testing Laboratory, Ballari, Karnataka.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00459.1

ABSTRACT:
The combination tablets dosage form of Telmisartan and Nebivolol hydrochloride dissolution method was developed by UV spectrophotometer and validated was according to the ICH guidelines. The any official method of this combination drugs was not available. In this proposed method two commercial brands of drug was used. The simultaneous estimation of Telmisartan and Nebivolol hydrochloride was performed in this proposed method which includes to solving of simultaneous equation. The wavelength of Telmisartan 296nm and 281nm of Nebivolol hydrochloride was used in this simultaneous equation. The dissolution mediums such as 0.1N HCl, phosphate buffer, SFG (without enzyme) at various ph was used in this method. The selected proposed dissolution method was SFG dissolution media (without enzyme) 900 ml, speed 75 rpm, USP type II apparatus and temperature at 37 ± 0.5°C and drug release than 85% within 45mints. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan and Nebivolol hydrochloride pharmaceutical combine tablets dosage form.
KEYWORDS:
Telmisartan, Nebivolol hydrochloride, Simultaneous equation, Dissolution, Validation, ICH guidelines.
Cite:
Chinmoy Kumar, Manish Kumar, Vipin Saini, Shailendra Bhatt, A. Pandurangan, Anuj Malik, Preeti Pal, Laxmi Narayan Shetty. Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using , UV Spectrophotometric Method. Research J. Pharm. and Tech. 2019; 12(6): 2742-2747.
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