2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  5

Year :  2019

Pages :   2189-2194

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Investigation of Antioxidant and Cytotoxic Activities of Kaempferia galanga L.



Address:   Imon Rahman1, Md. Tanvir Kabir1*, Md. Nasiful Islam1, Mushfiqa Muqaddim1, Shahana Sharmin1, Mohammed Sami Ullah1, Md. Sahab Uddin2
1Department of Pharmacy, BRAC University, Dhaka, Bangladesh
2Department of Pharmacy, Southeast University, Dhaka, Bangladesh
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00365.2

ABSTRACT:
This research was performed to determine the antioxidant, total phenolic content and cytotoxicity activities of methanol and acetone extracts of Kaempferia galanga Linn (Zingiberaceae) leaves. In this particular study, In vitro antioxidant activity of the extracts of Kaempferia galanga L. leaves was determined by using DPPH (2, 2-diphenyl-1-picrylhydraziyl) free radical scavenging assay. Here, both Standards butyl-1-hydroxyl toluene (BHT) and ascorbic acid (ASA) showed IC50 value of 28.30 µg/mL and 5.90 µg/mL. Compared to the standard crude methanol extract (CME) and crude acetone extract (CAE) showed IC50 value of 611.82 µg/mL and 702.79 µg/mL. In total phenolic content test, CME showed 1.012 mg of gallic acid equivalents/gm and CAE showed -0.066 mg of gallic acid equivalents/gm. Moreover, brine shrimp lethality bioassay was performed to determine the cytotoxic effect and the LC50 value of the CME and CAE were 4.78 µg/mL and 0.11 µg/mL. Whereas, LC50 value of the vincristine sulphate was 0.45 µg/mL. In conclusion, this research confirmed that Kaempferia galanga L. leaves comprised with antioxidant and cytotoxicity activity which can be used for various medicinal purposes.
KEYWORDS:
Kaempferia galanga L., Total phenol content, Antioxidant, DPPH free radical scavenging assay, Cytotoxicity.
Cite:
Imon Rahman, Md. Tanvir Kabir, Md. Nasiful Islam, Mushfiqa Muqaddim, Shahana Sharmin, Mohammed Sami Ullah, Md. Sahab Uddin. Investigation of Antioxidant and Cytotoxic Activities of Kaempferia galanga L.
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