2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  5

Year :  2019

Pages :   2167-2170

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells



Address:   Karpagam T1, Jannathul Firdous2*, Revathy1, Shanmuga Priya1, Varalakshmi B1, Gomathi S1, Geetha S3, Noorzaid Muhamad2
1Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, India.
2Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
3Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00360.3

ABSTRACT:
In the present study, anticancer and cytotoxicity of Aloe vera ethanolic leaves extract was evaluated as the leaves of A.vera are reported to have great medicinal value with potential therapeutic applications. The anticancer activities of the ethanolic leaves extract of A.vera were investigated using 3-(4,5-dimethylthiazole-2yl)-2,5-diphenyl tetrazolium bromide assay on three human cancer cell lines HepG2 (liver cancer), HeLa (human cervical carcinoma cell line) and A549 (human lung adenocarcinoma epithelial cell line).In anticancer studies, A.vera ethanolic leaves extract showed potent proliferation inhibitory activity against HepG2, HeLa and A549 cell lines. The results have shown that the A.vera ethanolic leaves extract contain some active ingredients with the potential of being anticancer agents. A.vera ethanolic leaves extract has the potential to fight against cancer cells. Further work should be carried out on the characterization of specific anticancer components of A.vera.
KEYWORDS:
Aloe vera, Cancer cell lines, Lipid peroxidation, MTT assay, Phytochemicals.
Cite:
Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad. Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells. Research J. Pharm. and Tech. 2019; 12(5):2167-2170.
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