2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  5

Year :  2019

Pages :   2145-2152

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities



Address:   Thant Zin1, J. Sivakumar2, C. Shanmuga Sundaram3, U. S. Mahadeva Rao1*
1Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
2PG and Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai – 603103
3PG and Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai – 603103
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00356.1

ABSTRACT:
Aim: The present investigation gives a detailed report on the analysis of the bioactive compound isolated from the sand crab Emerita asiatica is having better relation with vasoconstriction. Methods: The sand crab Emerita asiatica were collected from Thiruvidandhai beach located on the Kanchipuram District, Tamil Nadu, India, 41 K.M away from Chennai, on the East Coast Road route to Mahabalipuram. Sand crabs were collected by hand picking method. From the muscle mass of the Crab the organic compound was isolated by GC-MS analysis. Molecular docking was also performed to identify the protein ligand responsible for the constriction of blood vessels. Results: The isolated bioactive compound was identified as phenylephrine, an a1 adrenergic receptor which has the potential to lead the molecule for the vasoconstriction. In vitro studies of antibacterial activities clearly indicated that the different concentrations of phenylephrine have the antibacterial activity against the bacteria such as Klebsiella pneumoniae and Staphylococcus aureus. Summary: The present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs from marine organisms. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the vasoconstriction.
KEYWORDS:
Emerita asiatica; Klebsiella pneumoniae; Phenylephrine; Staphylococcus aureus; vasoconstriction.
Cite:
Thant Zin, J. Sivakumar, C. Shanmuga Sundaram, U. S. Mahadeva Rao. In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities. Research J. Pharm. and Tech. 2019; 12(5):2145-2152
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