2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  5

Year :  2019

Pages :   2141-2144

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis of Some Novel Flavanones and Evaluation of Antioxidant Activities



Address:   K. Ishwar Bhat, Ranee Kumari, Abhishek kumar, Pankaj Kumar*
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore-575018, Karnataka, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00355.X

ABSTRACT:
The novel series of substituted flavanones were synthesized by reacting various 2-hydroxy chalcones. The intermediate 2-hydroxy chalcones were synthesized by Claisen-Schmidt condensation reaction. Flavanones were prepared by refluxing 2-hydroxychalcones in ethanol in presence of conc. H2SO4. All the synthesized compounds (RF1-RF9) were assigned on the basis of IR, 1H-NMR and MASS spectral data. These synthesized compounds were evaluated for their antioxidant activity by two different methods, DPPH and nitric oxide method. The compounds RF1, RF2, RF6, and RF7, RF8 showed very good activity when compared to the standard.
KEYWORDS:
2-hydroxy chalcones, flavanones, antioxidant, DPPH, nitric oxide.
Cite:
K. Ishwar Bhat, Ranee Kumari, Abhishek kumar, Pankaj Kumar. Synthesis of Some Novel Flavanones and Evaluation of Antioxidant Activities. Research J. Pharm. and Tech. 2019; 12(5):2141-2144.
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