2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  3

Year :  2019

Pages :   1091-1095

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Facile and An Efficient Synthesis of 3,3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties



Address:   Sasikala Maadwar*1,2, Rajitha Galla1, Santhosh K. G2
1Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, India.
2Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00179.3

ABSTRACT:
A facile and an efficient synthesis of 3,3-disubstituted oxindole derivatives were synthesised by treating isatins with electron rich benzene derivatives at room temperature. The compounds were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds 5(9.2µM and 9.5µM) and 7(8.0µM and 10.4µM) exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, respectively.
KEYWORDS:
Isatins, Methoxy Benzenes, Boron Trifluoride Diethyl Etherate, MCF7 and SKVO3.
Cite:
Sasikala Maadwar, Rajitha Galla, Santhosh K. G. A Facile and An Efficient Synthesis of 3,3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties. Research J. Pharm. and Tech. 2019; 12(3): 1091-1095.
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