2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  12

Year :  2019

Pages :   5848-5854

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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New Hydrochlorothiazide Derivatives: Synthesis, Characterization and Anti-Microbial Assessments



Address:   Ayad Kareem Khan, Mohamed Dhiaa Hamdee
Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.01014.X

ABSTRACT:
A new series of hydrochlorothiazide derivatives linked to heterogeneous rings such as 1,3,4-thiadiazine [3], 3,5-dihydroxypyrazolidin [4], 6-hydroxy-2-thioxo-1,3,4-thiadiazinane [5] and diazenyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one [8] were prepared and characterized using FT-IR, 1H-NMR, 13C-NMR spectroscopic techniques and some physicochemical properties. These synthesized compounds were in vitro tested for their antimicrobial activity in the laboratory against several bacterial and fungus isolates. Each screened compounds exhibiting moderate to potent activity.
KEYWORDS:
hydrochlorothiazide, synthesis, characterization, antimicrobial.
Cite:
Ayad Kareem Khan, Mohamed Dhiaa Hamdee. New Hydrochlorothiazide Derivatives: Synthesis, Characterization and Anti-Microbial Assessments. Research J. Pharm. and Tech. 2019; 12(12): 5848-5854.
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