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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  12

Year :  2019

Pages :   5822-5826

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Evaluation of Pramipexole Dihydrochloride and Piperine Loaded Chitosan Nanoparticles for Improved Treatment of Parkinson’s Disease



Address:   Sujit Kumar, I. Somasundaram*
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advance Studies (VISTAS), Pallavaram, Chennai - 600117, Tamil Nadu, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.01008.4

ABSTRACT:
Nanoformulation plays important role to emphasize the efficiency of reaching of the drugs including chemotherapy drugs and Phytochemicals. Under this experiment we focused to improve the bioavailability of pramipexole dihydrochloride by loaded in nanoparticles, this may minimize the dosing frequency and may reduce the toxicity which is a side effect of conventional formulation. The polymer as a carrier plays an important role in transport the drug across the blood-brain barrier which may be effective in producing the therapeutic effect. Piperine as bio enhancer and MAO inhibitors may not only enhance the activity of pramipexole dihydrochloride but also provide additional mode of action to treat Parkinson’s disease in effective way moreover it may be used as a substituent of MAO-B inhibitors such as selegline and rosagline. This uplift the present work on particle size with respective towards two different drugs with a polymers.
KEYWORDS:
Parkinson’s Disease, Nanoparticles, Pramipexole hydrochloride, Piperine.
Cite:
Sujit Kumar, I. Somasundaram. Development and Evaluation of Pramipexole Dihydrochloride and Piperine Loaded Chitosan Nanoparticles for Improved Treatment of Parkinson’s Disease. Research J. Pharm. and Tech. 2019; 12(12): 5822-5826
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