2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  12

Year :  2019

Pages :   5752-5756

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Scientific and Methodical approach to developing the formulation of an Innovative Medicinal Product based on a derivative of 3,7-diazabicyclo [3.3.1]nonane (hydrindane)



Address:   G. E. Brkich*, N. V. Pyatigorskaya, N. B. Demina, O. A. Zyryanov, I. I. Krasnyuk
Sechenov First Moscow State Medical University, Trubetskaya Street, 8, Moscow, 119991, Russian Federation.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00996.X

ABSTRACT:
Different derivatives of 4-hydroxy-3-methoxy benzoic acid were synthesized and evaluated for their antioxidant, a-amylase inhibition and urease inhibition ability. Antioxidant evaluation was performed by DPPH radical scavenging assay and the results revealed that compounds 8, 10 and 13 as most active antioxidant agent with IC50 values of 43.09µg/ml, 44.59µg/ml and 43.43µg/ml respectively. a-Amylase inhibition study was performed using diastase by colorimetric method. Compound 9 showed maximum inhibition with IC50 value of 33.26 µg/ml. Compound 4 was found to possess maximum urease inhibition ability with IC50 value of 35.82µg/ml. Molecular docking study was performed using autodock software.
KEYWORDS:
Development of drug composition, derivatives of 3,7-diazabicyclo [3.3.1] nonane, brain-derived neurotrophic factor rehabilitation of patients after brain damage, nootropics, ampakines.
Cite:
G. E. Brkich, N. V. Pyatigorskaya, N. B. Demina, O. A. Zyryanov, I. I. Krasnyuk. Scientific and Methodical approach to developing the formulation of an Innovative Medicinal Product based on a derivative of 3,7-diazabicyclo [3.3.1]nonane (hydrindane). Research J. Pharm. and Tech. 2019; 12(12): 5752-5756.
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