2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  10

Year :  2019

Pages :   4735-4740

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Regulatory Mechanism of Caffeic acid on glucose Metabolism in Diabetes



Address:   Mohd Yusuf, Mohammad Nasiruddin, Nazneen Sultana, Badruddeen*, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahmad
Faculty of Pharmacy, Integral University, Lucknow (U.P), India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00816.3

ABSTRACT:
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, frequent urination, fatigue etc. It became prominent disorder affecting majority of the world population. Phenolic acids i.e. (caffeic acid) are sufficiently present in human dietary products. Hence there is need to evaluate the effect of commonly used phenolic acid compound on human health. Caffeic acid is naturally occurring phenolic compound commonly found in numerous plants, fruits, vegetables. It exhibits different pharmacological activities like anti-diabetic, anti-inflammatory, antioxidant, antimicrobial activities. Caffeic acid acts through different targets regulating the glucose metabolism. It elevates the AMPK level in skeletal muscles, liver, adipocytes and GLUT4 translocation and expression in skeleton muscles thus stimulate the glucose utilization. It also suppress the glucose output from liver. Caffeic acid inhibits the differentiation and adipogenesis. In addition it also helps to increase the exogenous antioxidant i.e. SOD, CAT, TBA, GRX and thus helps in reducing oxidative stress.
KEYWORDS:
Oxidative stress, Caffeic acid, Antioxidant, Diabetes mellitus.
Cite:
Mohd Yusuf, Mohammad Nasiruddin, Nazneen Sultana, Badruddeen, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahmad. Regulatory Mechanism of Caffeic acid on glucose Metabolism in Diabetes. Research J. Pharm. and Tech. 2019; 12(10):4735-4740.
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