2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  10

Year :  2019

Pages :   4657-4662

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Association of the ATP-binding Cassette Transporter A1 Gene Polymorphism with Lipid Profile and Type 2 Diabetes Mellitus



Address:   Abbas Sabbar Dakhil
Department of Physiology, Faculty of Medicine, University of Al-Qadisiyah, Iraq, 58001
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00802.3

ABSTRACT:
Diabetes remains unique among the main non-communicable ailments (NCDs) recognized by the World Health Organization (WHO), apart from the circulatory diseases, tumours, and long-lasting respiratory ailments. The current study aimed to determine the correlation between ABCA1 gene polymorphism and lipid profile in type 2 diabetes mellitus patients. Serum samples from 100 type 2 diabetes mellitus patients (46 males and 54 females) and 50 standard subjects (26 males and 24 females) were collected from Najaf province/Iraq. Fasting blood sugar (FBS), and lipid profiles (total cholesterol (TC), triglycerides (TG), HDL, LDL and VLDL) were measured. Polymerase chain reaction (PCR) with the Taq 1 enzyme was used for the amplification of the ABCA1 gene, which contains 525bp of the ABCA1 gene in the locus V825I. The present study revealed a positive correlation between FBS and body mass index (BMI) (r = 0.2390, p = 0.0463), TG (r = 0. 1836, p = .01743), and VLDL (r = 0.1836, p = 0.1839). The frequencies of the GG genotype and the G allele were higher in the normal groups compared to the patients (58% vs. 56% and 70% vs. 67%, respectively); conversely, the frequencies of the AA genotype (18% vs. 22%) and the A allele (30% vs. 33%) were higher in the patients compared to the normal groups. The data also showed a significant relationship between ABCA1 gene polymorphism and both TG and VLDL (P=0.007 for each). There is relationship between the ABCA1 gene and HDL level. Additionally, the G allele could be a defensive factor against diabetes mellitus in Iraqi people.
KEYWORDS:
ABCA1 gene; lipid profile; type 2 diabetes mellitus; HDL.
Cite:
Abbas Sabbar Dakhil. Association of the ATP-binding Cassette Transporter A1 Gene Polymorphism with Lipid Profile and Type 2 Diabetes Mellitus. Research J. Pharm. and Tech 2019; 12(10):4657-4662.Research J. Pharm. and Tech 2019; 12(10):4657-4662.
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