2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   4047-4050

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Synthesis, Characterization and Biological Evaluation of some Novel 1,3 Oxazepine derivatives from Vanillin Schiff’s Bases



Address:   Khudhayer J. Kadem, Murad G. Munahi
Department of Chemistry, College of Science, University of Babylon, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00745.X

ABSTRACT:
A series of Schiff’s bases and their novel derivatives (Oxazepines) have been synthesized , 4-hydroxy-3-methoxy benzaldehyde (vanillin) was condensed with different amines to produce the Schiff’s bases in the presence of glacial acetic acid as a catalyst or KOH , novel five 1,3-oxazepine derivatives have been synthesized through reaction of Schiff’s bases with succinic anhydride and maleic anhydride using acidic catalyst. The identification was performed using, FT-IR and1H-NMRspectroscopies. The synthesized1,3-oxazepine derivatives were biologically screened against gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli) . The results was showed excellent to moderate anti-bacterial activity.
KEYWORDS:
1,3-oxazepine, Vanillin, Schiff’s bases, anti-bacterial activity, disk diffusion method, cycloaddition.
Cite:
Khudhayer J. Kadem, Murad G. Munahi. Synthesis, Characterization and Biological Evaluation of some Novel 1,3 Oxazepine derivatives from Vanillin Schiff’s Bases. Research J. Pharm. and Tech 2018; 11(9): 4047-4050.
[View HTML]     



Visitor's No. :   655107