Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3969-3972

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives



Address:   K. Ishwar Bhat*, B. C. Revanasiddappa, M. Vijay Kumar, Banylla Felicity, Ranee Kumari, Abhishek Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of NITTE
(Deemed to be University), Paneer, Deralakatte, Mangalore-575 018, Karnataka, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00729.1

ABSTRACT:
A new series of Chalcones (2a-i) were prepared by Claisen-Schmidth Condensation reaction involving substituted aromatic aldehydes and aromatic ketones in alcohol medium, in presence of 40% NaOH as base. The title compounds Pyrazolines (3a-i) were synthesized by reacting Chalcones (2a-i) and 2-thiophene carbohydrazide (1) in glacial acetic acid medium. The final synthesized compounds were screened for their In-vitro anti-inflammatory activity by egg albumin denaturation method and protein denaturation method. The structures of the newly synthesized compounds were assigned on the basis of IR, 1H-NMR and Mass spectral data. The compounds 3b, 3c, 3d and 3f also showed good inhibition when compared to the standard diclofenac sodium
KEYWORDS:
Chalcones, Pyrazolines, Anti-inflammatory activity, Protein denaturation method.
Cite:
Ranee Kumari, Abhishek Kumar. Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives. Research J. Pharm. and Tech 2018; 11(9): 3969-3972.
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