Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3947-3949

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Reationary ability of 3,5-Dibromo-N-Phenylanthranilic acids Derivatives



Address:   Diana. A. Alferova, Elena N. Svechnikova, Marharyta M. Suleiman, Ivan S. Gritsenko, Gennadiy P. Kazakov, Natalya V. Popova, Olga V. Kiz, Vitaliy D. Yaremenko
Department of Nutriciology and Pharmaceutical Bromatology, National University of Pharmacy, Ukraine, Kharkiv
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00725.4

ABSTRACT:
The study of the acid-base properties of substituted N-phenylanthranilic acid is the important since, because it will allow the design of medicinal substances of this series with already known predictive properties. Therefore we have been studiedthe reactivity of 3,5-dibromo-N-phenylanthranilic acids has been studied. Reactivity of this isostructural group is studied in reversible conditions. The acid-base properties of 11 substituted of 3,5-dibromo-N-phenylanthranilic acids have been studied in a mixed solvent of dioxane-water (60 vol. % dioxane) at 250?. It has been established that substitutes and their position in non-anthranilic fragment of a molecule influence on the avidity of these acids.
KEYWORDS:
Anthranilic acid, reationary ability, acid-base properties, titration,Hammett’s equation
Cite:
Diana. A. Alferova, Elena N. Svechnikova, Marharyta M. Suleiman, Ivan S. Gritsenko, Gennadiy P. Kazakov, Natalya V. Popova, Olga V. Kiz, Vitaliy D. Yaremenko. Reationary ability of 3,5-Dibromo-N-Phenylanthranilic acids Derivatives. Research J. Pharm. and Tech 2018; 11(9): 3947-3949.
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