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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3932-3936

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and characterization of Irbesartan Co-Crystals

Address:   Akhil Nair, Harini R, Melissa P, Krupali Shah, Usha Y Nayak*, Mahalaxmi R, Vamshi Krishna T
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India–576104
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00722.9

The aim of the work was to prepare co-crystals of irbesartan (IBS), a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid and benzoic acid co-crystals were formed with good physicochemical properties. The solid-state characterization of co-crystals was studied by FTIR, DSC, and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. There was a 2-fold increase in the aqueous solubility and 4-8 fold increase in dissolution rate of co-crystals. Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus, developed co-crystals were found to be a suitable alternative to increase the solubility and dissolution rate of IBS.
Irbesartan, co-crystals, solvent evaporation, benzoic acid, bioavailability
Akhil Nair, Harini R, Melissa P, Krupali Shah, Usha Y Nayak*, Mahalaxmi R, Vamshi Krishna T. Development and characterization of Irbesartan Co-Crystals. Research J. Pharm. and Tech 2018; 11(9): 3932-3936.
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