Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3923-3926

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Studies on Influence of Polypropylene Foam Powder on Gastroretentive properties of Floating tablets of Cefditoren Pivoxil



Address:   Naga Raju Kandukoori1*, Fasiha Maimanath1, K. Ravali1, Syeda Warda Jameel1, Deepika B1, Y. Narsimha Reddy2
1Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, TS.
2Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Hanumakonda, Warangal, TS.
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00720.5

ABSTRACT:
In the present study, the floating properties of prepared tablets were examined mainly. Total four formulations (F1 to F4) were prepared by using polymers like HPMC K4M and HPMC K15M. Each polymer has been used along with two different floating agents like polypropylene foam powder (PFP) and sodium bicarbonate. In such a way each polymer has been used in two formulations. All prepared tablets were evaluated for their physicochemical properties like weight variation, friability, hardness and drug contents. Formulations F1 and F3 containing PFP as floating agent, have shown good floating properties compared to the formulations F2 and F4 containing sodium bicarbonate as floating agent. All the four formulations have controlled the drug release up to 8 hours.
KEYWORDS:
Cefditoren pivoxil, Polypropylene foam powder, gastroretentive, floating lag time, HPMC K4M.
Cite:
Naga Raju Kandukoori, Fasiha Maimanath, K. Ravali, Syeda Warda Jameel, Deepika B, Y. Narsimha Reddy. Studies on Influence of Polypropylene Foam Powder on Gastroretentive properties of Floating tablets of Cefditoren Pivoxil. Research J. Pharm. and Tech 2018; 11(9): 3923-3926.
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