Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3897-3899

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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The Biochemical Response of Acetyl Cholinesterasein Prostate Cancer in relation to the Environment



Address:   Jaleel Ibrahim Asaad1, Ayad M. J. Al-Mamoori2, Hussein Mahmood Shukri3, Asmaa Ibrahim Sail1, Enas Shehab Ahmed1, Aya Nadhmi4
1Biotechnology Research Center, AL-Nahrin University, Iraq
2Biology Dept., College of Science , University of Babylon, Iraq
3Biotechnology College, AL-Nahrin University, Iraq
4Biochemistry Departments, Ottawa University, Canada
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00714.X

ABSTRACT:
Acetylcholinesterase (ACHE) is an enzyme. Its main extracellular function isto hydrolyze the Acetylcholine to choline and acetate,and maintain the correct levels of Acetylcholine in the body and according to the Environmental Factors. Another function for (ACHE) in intra cellular compartment is to stimulate cell proliferation and apoptosis. In this study, we try to investigate the (ACHE) and prostate cancer overlapping to get new diagnostic markerand/or treatment for prostate cancer. Results: There is no significant difference in serum (ACHE) of patients with prostate cancer (12.90 ± 4.17ng /ml), in comparison to control group (9.0 ± 1.78 ng /ml),(p>0.05). But there is significant increase in serum (ACHE) incases with high grade prostate cancer with Gleason grade more than 7,(11.90 ± 2.11ng /ml),in comparison to lower grade prostate cancerwith Gleason grade less than 7, and control group (10.20 ± 2.20and 9.0 ± 1.78ng /ml respectively),(p<0.05). Conclusion: Because of thevariation inthe level of serum (ACHE) in patients with prostate cancer, this marker can't consider as prognostic protein for diagnosis ofprostate cancer. However further prospective studies are recommended to demonstrate its role in the diagnosis, grading and elimination of the tumor.
KEYWORDS:
Acetyl Cholinesterasein, Prostate Cancer
Cite:
Jaleel Ibrahim Asaad, Ayad M. J. Al-Mamoori, Hussein Mahmood Shukri, Asmaa Ibrahim Sail, Enas Shehab Ahmed, Aya Nadhmi. The Biochemical Response of Acetyl Cholinesterasein Prostate Cancer in relation to the Environment. Research J. Pharm. and Tech 2018; 11(9): 3897-3899.
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