2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  9

Year :  2018

Pages :   3745-3751

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Sugar Palm Fruit (Arenga pinnata) Diminish Pain and Inflammatory Symptoms of Osteoarthritis in male Wistar Rat (Rattus norvegicus)



Address:   UmiKalsum1, Husnul Khotimah1, Wibi Riawan2, Hasnia Azizah Trisnaini3, Elok Zubaidah3
1Departement of Pharmacology, Medical School, Universitas Brawijaya, Indonesia
2Departement of Biochemistry and Molecular Biology, Medical School, Universitas Brawijaya, Indonesia
3Agricultural Technology Faculty,Universitas Brawijaya, Indonesia
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00686.8

ABSTRACT:
Sugar palm fruit is the seed of Aren fruit (Arenga pinnata) that contain galactomannan polysaccharides. Galactomannan is the polysaccharide that has analgesic activity. The purpose of this research was to determine the effect of analgesic and anti-inflammation of sugar palm fruit juice to the inflammation induced by 0.6% acetic acid and Complete Freund's Adjuvant (CFA) to male Wistar rats (Rattus norvegicus) respectively. Sugar palm fruit juice made by blending the sugar palm fruit and water which ratio 1:2. The male rats were divided into 6 groups: control, induced with acetic acid 0.6% (analgesic) or CFA (inflammation), induced with acetic acid 0.6% (analgesic) or CFA (inflammation) and sodium diclofenac 10 mg/200 g BW of rats, and last three groups were induced by acetic acid or CFA and administered by sugar palm fruit extract dose 1, 2 and 3 mg/200 g BW. We used Fourier Transform Infrared (FITR) analysis to identify molecular structure of galactomannan in sugar palm fruit juice. The results showed that sugar palm fruit juice reduced pain and edema in rats. The highest efficacy of analgesic and anti-inflammatory response was at 3 ml/200 g BW sugar palm fruit juice which potension of analgesic was 69.7% and anti-inflammatory response to decrease edema volume was 1,608 ml. FITR peaks showed that galactomannan had main chain ß-(1-4)-D_mano-pyranose and bind to D-galacto pyranose in a-1-6 chain. It could be concluded that sugar palm fruit juice potential to developed as analgesic and anti-inflammatory agent.
KEYWORDS:
Anti-Inflammation, Anti analgesic, Galactomannan, Sugar palm fruit, Osteoarthritis
Cite:
UmiKalsum, Husnul Khotimah, Wibi Riawan, Hasnia Azizah Trisnaini, Elok Zubaidah. Sugar Palm Fruit (Arenga pinnata) Diminish Pain and Inflammatory Symptoms of Osteoarthritis in male Wistar Rat (Rattus norvegicus). Research J. Pharm. and Tech 2018; 11(9): 3745-3751.
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