2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  7

Year :  2018

Pages :   3013-3017

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis, Characterization and Antimicrobial Screening of Substituted Indanone Derivatives



Address:   Prafulla Sabale1*, Tinkal Gupta3, Vidya Sabale2
1Professor in Pharmaceutical Chemistry, Department of Pharmaceutical Sciences R.T.M. Nagpur University Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440033 India
2Dadashab Balpande College of Pharmacy, Manewada Road, Besa Chowk, Nagpur-440037 India
3Department Pharmaceutical Sciences R.T.M. Nagpur University Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440033 India
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00555.3

ABSTRACT:
Indanone acetic acid is a non-heterocyclic fused ring of benzene attached to cyclopentananone moiety with acetic acid side chain at 1-position. A simple and efficient method has been developed for the synthesis by condensation of indanone acetic acid with various substituents like aniline, o-toludine, 2-chloroaniline, 3-chloroaniline, o-anisidine, and p-fluoroaniline to obtain substituted indanone acetic acid (5a-f) derivatives. The newly synthesized compounds were structurally con?rmed by analytical and spectral data and evaluated for their antimicrobial activities. Antimicrobial activity of synthesized compounds were screened by using gram positive Staphylococcus aureus, Bacillus subtilis and gram negative Escherichia coli and Salmonella typhi microbial cultures and fungal strains Candida albicans and Aspergillus niger with reference to standard drug. The results showed that para-fluorophenyl substituted indanone acetic acid (5f) derivative exhibited marked potency as antimicrobial agents and ortho-methoxyphenyl (5d) derivative exhibited better antifungal activity.
KEYWORDS:
1-Indanone; Indanone acetic acid; Antimicrobial activity; Antifungal activity.
Cite:
Prafulla Sabale, Tinkal Gupta, Vidya Sabale. Synthesis, Characterization and Antimicrobial Screening of Substituted Indanone Derivatives. Research J. Pharm. and Tech 2018; 11(7): 3013-3017.
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