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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  7

Year :  2018

Pages :   2809-2813

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Molecular Characterizations of Aminoglycoside Modifying Enzymes of Proteus mirabilis Isolated From Patients in Al-Qadisiyah Governorate



Address:   Najlaa Abdallah D. AL-Oqaili1, Majed Kadim AL-Shebli2, Azhar N. H. Almousawi3
1College of Biotechnology, University of Al-Qadisiyah, Iraq
2College of Education, University of Al-Qadisiyah, Iraq
3College of Pharmacy,University of Al-Qadisiyah, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00518.8

ABSTRACT:
The aim of this study was evaluate the presence of modified enzymes for aminoglycosides antibiotics in Proteus mirabilis. Total of 64 clinical isolates were collected from various sources included urine, middle ear, wounds, burns, high cervical and endometrium cervical, which was taken from in patients and outpatients in Maternal, and General Teaching Hospital in AL- Diwaniya city during the period from 1/3/2015 till 30/9/2015. Select the minimum inhibitory concentration of a number of antibiotics for aminoglycosides for resistant bacterial isolates which are anti-Gentamycin, Tobramycin, Kanamycin, Streptomycin, Netlimicin the isolates showed their ability to grow in high concentrations ranging from (32-1024)µg/ml, also resisted anti-aminoglycosides and with different rates of Gentamycin, Amikacin ,Tobramycin , Kanamycin, Streptomycin, and Netlimicin, it was in varying proportions (54.68, 31.25, 76.56, 81.25, 85.93, 81.25) %, respectively .
KEYWORDS:
Aminoglycoside, Modifing Enzymes, proteus mirabilis, PCR, MIC, Aminoglycoside antibiotics.
Cite:
Najlaa Abdallah D. AL-Oqaili, Majed Kadim AL-Shebli, Azhar N. H. Almousawi. Molecular Characterizations of Aminoglycoside Modifying Enzymes of Proteus mirabilis Isolated From Patients in Al-Qadisiyah Governorate. Research J. Pharm. and Tech 2018; 11(7): 2809-2813.
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