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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  7

Year :  2018

Pages :   2765-2767

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial Evaluation of Some Novel Mercapto Pyrimidine via Pyrrole Chalcone



Address:   Pankaj Kumar1, Abhishek Kumar1*, Prashant Nayak2, Geena3, Bhashini3
1Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore 575018, Karnataka, India.
2Department of Pharmaceutics Nitte (Deemed to be University) Paneer, Deralakatte-575018, Mangalore, Karnataka.
3NGSM Institute of Pharmaceutical Sciences Nitte (Deemed to be University) Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00511.5

ABSTRACT:
In an effort to develop antimicrobial agents, a series of mercaptopyrimidines were prepared by condensation of appropriate 3 Acetyl-2,4-dimethyl pyrrole with appropriate aromatic aldehydes in the presence of H2SO4 at room temperature. The final synthesized mercapto pyrimidine derivatives is prepared by the cyclization of pyrrolylchalcones with thioureain presence of KOH as base The synthesized compounds were characterized by means of their IR, Mass 1H-NMR spectral data. All the compounds were tested for their antibacterial and antifungal activities by the cup plate.
KEYWORDS:
3Acetyl-2,4-dimethyl pyrrole, Pyrrolylchalcones. Mercapto pyrimidine, Antibacterial.
Cite:
Pankaj Kumar1, Abhishek Kumar, Prashant Nayak, Geena, Bhashini. Synthesis and Antimicrobial Evaluation of Some Novel Mercapto Pyrimidine via Pyrrole Chalcone. Research J. Pharm. and Tech 2018; 11(7): 2765-2767
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