2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   1685-1690

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Nanocrystals: A Newer Technological Advancement in Drug Delivery



Address:   Neha Xalxo, Anup Naha, Abhishek Dhoot, Juhi Priya
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka - 576104, INDIA
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00314.1

ABSTRACT:
Solubility is defined as dissolution of a solute in a solvent to give a homogenous system. It is an important consideration which is required to achieve appropriate drug concentration in systemic circulation for a chosen pharmacological response. With innovation in technologies, the discoveries of drugs having better efficacy are restricted due to poor solubility, despite having clinical efficacy. Hence it has become a major challenge. More than 50% new chemical entities produced in pharmacy industry are practically insoluble in water. Nano crystals have potential to overcome this issue. They have size in nanometer range (mean diameter < 1000nm) which changes the drug properties dramatically. This review article summaries different methods of preparation, various production technologies available currently in industries; evaluation techniques, applications of nano crystal formulation, future trends and challenges of nano crystal formulation, and various marketed dosage forms developed using nano crystals are discussed.
KEYWORDS:
Nanocrystal, Solubility, Bioavailability, Drug Delivery
Cite:
Neha Xalxo, Anup Naha, Abhishek Dhoot, Juhi Priya. Nanocrystals: A Newer Technological Advancement in Drug Delivery. Research J. Pharm. and Tech 2018; 11(4): 1685-1690.
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