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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   1685-1690

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Nanocrystals: A Newer Technological Advancement in Drug Delivery

Address:   Neha Xalxo, Anup Naha, Abhishek Dhoot, Juhi Priya
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka - 576104, INDIA
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00314.1

Solubility is defined as dissolution of a solute in a solvent to give a homogenous system. It is an important consideration which is required to achieve appropriate drug concentration in systemic circulation for a chosen pharmacological response. With innovation in technologies, the discoveries of drugs having better efficacy are restricted due to poor solubility, despite having clinical efficacy. Hence it has become a major challenge. More than 50% new chemical entities produced in pharmacy industry are practically insoluble in water. Nano crystals have potential to overcome this issue. They have size in nanometer range (mean diameter < 1000nm) which changes the drug properties dramatically. This review article summaries different methods of preparation, various production technologies available currently in industries; evaluation techniques, applications of nano crystal formulation, future trends and challenges of nano crystal formulation, and various marketed dosage forms developed using nano crystals are discussed.
Nanocrystal, Solubility, Bioavailability, Drug Delivery
Neha Xalxo, Anup Naha, Abhishek Dhoot, Juhi Priya. Nanocrystals: A Newer Technological Advancement in Drug Delivery. Research J. Pharm. and Tech 2018; 11(4): 1685-1690.
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