2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   1522-1526

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Insilico approach of interaction studies in Bacopa monnieri compounds targeting multi-proteins for Alzheimer’s Disease



Address:   S. Lakshmi kanthamma1, Joyita Kriszhnamurthi1, C. N. Hemalatha1a, M. Vijey Aanandhi2*
1Department of Pharmacy Practice, Vels Institute of Science Technology and Advanced Studies, (VISTAS), Chennai- 600117.
1aResearch Scholar, Department of Pharmaceutical Chemistry, Vels Institute of Science Technology and Advanced Studies, (VISTAS), Chennai- 600117.
2 *Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, (VISTAS), Chennai- 600117.
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00283.4

ABSTRACT:
Bacopa monnieri Linn (plantaginaceae) is perennial, creeping herb native to the wetlands of southern and eastern India, Australia, Europe and Asia. It is a well-known medicinal plant, is widely used in traditional medicine system in the treatment of epilepsy, asthma, gastrointestinal discomfort, skin disease and has antimicrobial action, antioxidant and anticancer. It is a nootropic and used as memory enhancer and reducing anxiety in the treatment of attention deficit hyperactivity disorder. Bacopa monnieri (also known as Brahmi) is used in the treatment of Alzheimer’s disease. The objective of this study was to establish the binding energy of Bacopa monnieri biological active compounds and drug likeliness by Insilico techniques for treatment of Alzheimer’s disease with CASP3. The compounds taken were apigenin, rosavin and luteolin. These compounds are docked by using AutoDock 4.2 Software with proteins selected based upon the literature survey and the PDB IDs are 5IAS, 5IAR, 5IAJ, and 5IBC. From the docking results the compounds shows satisfactory dock score values respectively. These compounds are visualized by using Discovery studio 4.1 Visualizer followed by DruLiTo software which satisfies the Lipinski’s properties for all the compounds. This result depicts the Bacopa monneri derivatives having significant role to design new compounds with these properties for treating Alzheimer’s disease.
KEYWORDS:
Bacopa monnieri; Lipinski’s rule; AutoDock 4.2; Discovery Studio Visualizer 4.1.
Cite:
S. Lakshmi kanthamma, Joyita Kriszhnamurthi, C. N. Hemalatha, M. Vijey Aanandhi. Insilico approach of interaction studies in Bacopa monnieri compounds targeting multi-proteins for Alzheimer’s Disease. Research J. Pharm. and Tech 2018; 11(4): 1522-1526.
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