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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   1429-1435

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Characterization of Mouth Dissolving Tablets of Dexamethasone Using Synthetic Superdisintegrants

Address:   Venkatalakshmi Ranganathan1*, Ng Jeng Ho2, Ravi Sheshala3, Sasikala Chinnappan4
1Faculty of Pharmacy, MAHSA University, Jalan SP 2/7, Bandar Saujana Putra, Jenjarom, Selangor, Malaysia-41200.
2Multicare Health Pharmacy Sdn Bhd, No 1, Lengkok Puteri Utama, Bandar Puteri, 47100 Puchong, Selangor, Malaysia
3Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300 Puncak Alam, Kuala Selangor, Malaysia.
4Faculty of Pharmaceutical Sciences, UCSI University, Jalan Menara Gading 1, Taman Connaught, 56000 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00267.6

Background: Dexamethasone is a synthetic glucocorticoid hormone that is commonly used as antiemetic agent with the combination of Ondansetron. The present research is undertaken to formulate mouth dissolving dexamethasone with different superdisintegrants and to study its drug release profile in human saliva. Methods: Scanning of lambda max and drug-polymer compatibility studies were done for pre formulation studies. Mouth dissolving dexamethasone tablets were formulated using direct compression method with different concentrations of different superdisintegrants. Post compression studies were done after that. The final step of the studies was in-vitro drug release studies. Results: Lambda max was determined at 239nm. A calibration curve with R2 = 0.9984 was obtained. Dug-polymer compatibility studies showed no interactions between the pure drug sample and the polymers. All formulations have complied with USP specification limit in every physicochemical parameter for a conventional tablet. All formulations released drug completely at the end of 60 minutes. Conclusion: The formulated mouth dissolving dexamethasone tablets do disintegrate and dissolve rapidly in human saliva. The formulated mouth dissolving tablets showed more rapid drug release as compared to conventional marketed product.
Dexamethasone, mouth dissolving tablets, superdisintegrants, croscarmellose sodium, crospovidone
Venkatalakshmi Ranganathan, Ng Jeng Ho, Ravi Sheshala, Sasikala Chinnappan. Formulation and Characterization of Mouth Dissolving Tablets of Dexamethasone Using Synthetic Superdisintegrants. Research J. Pharm. and Tech 2018; 11(4): 1429-1435.
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