2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   705-710

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Compartment Between Breast Cancer Patient Undergoing Chemotherapy and Healthy Women by Cytokinesis-block Micronucleus testand Nuclear Division Index



Address:   Sara jawad kadhem¹, Dr. AbdulSahib K. Ali², Abdul-Ameer N. AL_rikabi¹
¹Department of Biology, College of Science, AlMustansiriyah University, Baghdad, Iraq
²Ministry of Science and Technology, Central Laboratories Directorate, Baghdad, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00133.6

ABSTRACT:
One of tests to measurement the effect for toxogintic material or some drugson chromosomes like chemotherapy or radiotherapy are micronucleus test (MNT) and nuclear division index (NDI), MNT and NDI easy tests and rapidly so in this study comparing between healthy women and breast cancer patients undergoing chemotherapy by notice the number of MN cell in peripheral lymphocytes and NDI to know chemotherapy effect on patient’s chromosomes. high frequency of MN in breast cancer noticed from than control and less of NDI frequency in breast cancer from than control, this result happened because the effect of chemotherapy on chromosomes and broken it so the MN increased and and made it appear, chemotherapy made cell division decreased and cell death and necrosis increased.
KEYWORDS:
Micronucleus test (MNT),nuclear division index(NDI),breast cancer (BC),peripheral blood lymphocytes (PBL).
Cite:
Sara jawad kadhem, AbdulSahib K. Ali, Abdul-Ameer N. AL_rikabi. Compartment Between Breast Cancer Patient Undergoing Chemotherapy and Healthy Women by Cytokinesis-block Micronucleus testand Nuclear Division Index. Research J. Pharm. and Tech 2018; 11(2):705-710.
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