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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  12

Year :  2018

Pages :   5408-5412

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antioxidant Activity of Some New Coumarin Incorporated 4-Thiazolidinone Derivatives



Address:   K. Ishwar Bhat, Apoorva A, Abhishek Kumar, Pankaj Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00987.3

ABSTRACT:
A series of new 4-thiazolidinone derivatives were synthesized by reacting various coumarinyl schiff bases with thioglycollic acid. The intermediate coumarinyl schiff bases were synthesized by reacting 4-hydroxyl coumarin with various substituted anilines in alcohol medium. All the newly synthesized compounds were assigned on the basis of IR, 1H NMR and mass spectral data. All the newly synthesized compounds were evaluated for in-vitro antioxidant activities like DPPH, nitric oxide and hydrogen peroxide radical scavenging assay models. Most of the synthesised compounds showed good antioxidant activity.
KEYWORDS:
Coumarins, Thiazolidinones, Antioxidant activity
Cite:
K. Ishwar Bhat, Apoorva A, Abhishek Kumar, Pankaj Kumar. Synthesis and Antioxidant Activity of Some New Coumarin Incorporated 4-Thiazolidinone Derivatives. Research J. Pharm. and Tech 2018; 11(12): 5408-5412.
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