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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  12

Year :  2018

Pages :   5332-5336

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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The Development of Identification and Quantitative Definition Methodic of Active substances of the Ointment “Allergolic”



Address:   Rukhmakova Olga, Yarnykh Tatyana, Tykhonov Olexander
National University of Pharmacy, Valentynovskaya Str. 4, Kharkov, Ukraine 61168
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00970.8

ABSTRACT:
Objectives: to develop identification and quantitative definition methodic of active substances of the ointment “Allergolic”. Materials and Methods: the development of identification and quantitative definition methodic of licorice root dry extract and terbinafine hydrochloride in the experimental series of the ointment “Allergolic” was carried out by HPLC method. To determine the glycyrrhizin acid (GA) used the modification of the procedure described in the State Pharmacopoeia, validation was carried out only for proof of specificity. The method for determining terbinafine hydrochloride has been validated according to the «Specificity» and «Linearity» indices. To confirm the presence of lavender essential oil in the medicine, its identification and quantitative determination using the gas chromatography method was performed in accordance with the requirements of the State Pharmacopoeia. Results and Discussions: based on the conducted research we have developed identification and quantitative definition methodic of active substances of the ointment “Allergolic”, description of which is given in the article. Conclusion: using the HPLC method, an identification was made and the content of GA and terbinafine hydrochloride in the medicine was determined. The content of GA was 13.12 mg, the content of terbinafine hydrochloride - 5.07 mg per gram of the ointment. The methodic of identification and quantitative determination of lavender essential oil in the ointment by the gas chromatography method was proposed. Its content ranged from 4.5 mg to 5.75 mg.
KEYWORDS:
ointment, development, identification, quantitative definition, methodic, active substances.
Cite:
Rukhmakova Olga, Yarnykh Tatyana, Tykhonov Olexander. The Development of Identification and Quantitative Definition Methodic of Active substances of the Ointment “Allergolic”. Research J. Pharm. and Tech 2018; 11(12): 5332-5336.
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