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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  12

Year :  2018

Pages :   5293-5296

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Cardioprotective Activity of Telmisartan, Metformin and its Combination against Doxorubicin Induced Myocardial Infarction in Rat Model



Address:   P. Aruna1, N. M. Gayathiri2
1Department of Pharmacology, PSG College of Pharmacy, Coimbatore.
2Assistant Professor , Department of Pharmacology, Swamy Vivekanandha College of Pharmacy, Tiruchengode- 637 205
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00964.2

ABSTRACT:
Objective: The present study was designed to investigate the cardioprotective activity of telmisartan, metformin and its combination against doxorubicin induced myocardial infarction in rat by biochemical analysis. Methods: The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The study was conducted in albino wister rats (n=24) by using doxorubicin as negative control. the test drug, telmisartan and metformin was given alone and in combination for 15 days orally, on 14th & 15th day doxorubicin(15mg/kg) was injected intraperitoneally after the drug admistration except the normal control group. Results: The biochemical parameters, Troponin T shown to be negative for drug treated groups and positive for doxorubicin group (negative control). lactate dehydrogenase and CK-MB decreased for drug treated group then the negative control. Conclusion: These results suggest that the telmisartan and metformin treatment provides a significant cardioprotecive protective effect against acute-doxorubicin induced myocardial infarction in rats.
KEYWORDS:
Telmisartan, Metformin, doxorubicin, cardiotoxicity, cardioprotective effect.
Cite:
P. Aruna, N. M. Gayathiri. Cardioprotective Activity of Telmisartan, Metformin and its Combination against Doxorubicin Induced Myocardial Infarction in Rat Model. Research J. Pharm. and Tech 2018; 11(12): 5293-5296.
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