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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  11

Year :  2018

Pages :   4974-4976

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Cytotoxicity of 8-Anilino 1-Naphthalene Sulfonic acid and its Degradation Products



Address:   Valli Nachiyar C*, Renugadevi K, Swetha Sunkar
Department of Biotechnology, Sathyabama University, Chennai, Tamil Nadu
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00906.X

ABSTRACT:
8-Anilino 1-Naphthalene sulfonic acid is an aromatic amine used extensively in the synthesis of azo dyes. This compound is also produced as an intermediate compound in the bacterial degradation of azo dyes during azo reduction. Moraxella osloensis, a bacterium with dye degrading ability, was checked for its ability to degrade this aromatic amine and the organism was found to be capable of degrading 64% of 20 mg l-1 this amine. The cytotoxicity of this aromatic amine and its degradation products were checked in vitro using HEp2 (human epithelial type 2) and 3T3 (mouse embryonic fibroblast) cell lines. The results indicated the decreased toxicity of the degradation products compared to the aromatic amine. The normal cells were more sensitive to both the aromatic amine and its degradation products compared to the cancer cell lines.
KEYWORDS:
Moraxella osloensis, Anilino Naphthalene Sulfonic acid (ANSA), Biodegradation: cytotoxicity
Cite:
Valli Nachiyar C, Renugadevi K, Swetha Sunkar. Cytotoxicity of 8-Anilino 1-Naphthalene Sulfonic acid and its Degradation Products. Research J. Pharm. and Tech 2018; 11(11): 4974-4976.
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