Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  11

Year :  2018

Pages :   4892-4898

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Fexofenadine Buccal Mucoadhesive Patches



Address:   Arifa Begum Sk1*, Sravya AHLB2, Deepika BGD2, Naga Manasa G2, Srujana M2, Uma V2, Lakshmi Tejeswari S2, Padmalatha K2
1Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur – 522034, Andhra Pradesh, India.
2Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada – 521108, Andhra Pradesh, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00891.0

ABSTRACT:
Mucoadhesive buccal patches for the delivery of fexofenadine using various polyvinyl alcohol, hydroxypropyl methyl cellulose K4M and K15M and Eudragit L100 were developed using solvent casting technique. The fabricated formulations were evaluated for different physicochemical as well as mechanical parameters such as thickness, surface pH, weight uniformity, swelling index, folding endurance, drug content, percentage moisture loss, in vitro dispersion and in vitro residence time. An in vitro drug release study was designed and performed using freshly prepared egg membrane as semi-permeable membrane. The optimized formulation (F1) showed maximum percentage of drug release 96.18% ± 0.53% by the end of 8 h. The sustained release of the drug was achieved up to 8 h.
KEYWORDS:
Buccal delivery, mucoadhesivde patches, polyvinyl alcohol, hydroxypropyl methyl cellulose, folding endurance.
Cite:
Arifa Begum Sk, Sravya AHLB, Deepika BGD, Naga Manasa G, Srujana M, Uma V, Lakshmi Tejeswari S, Padmalatha K. Formulation and Evaluation of Fexofenadine Buccal Mucoadhesive Patches Research J. Pharm. and Tech 2018; 11(11): 4892-4898.
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