Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  11

Year :  2018

Pages :   4773-4780

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antidiabetic Effect of Ammania baccifera Linn leaf on Streptozotocin Induced Diabetes in Male Albino Wistar Rats



Address:   B. D. Patel, M. L. Kori*
RKDF University, Airport Bypass Road, Gandhi Nagar, Bhopal, Madhya Pradesh, 462033, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00869.7

ABSTRACT:
Background: Diabetes has been increasing at an alarming rate around the world, and experts have relied on remedies from the utilization of ancient drugs that are essentially derived from plants. Aim: The present study aimed to evaluate the antidiabetic potential of Ammania baccifera Linn leaf extracts on streptozotocin induced diabetic rats. Materials and Methods: Diabetes was induced in male albino wistar rats by single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). The diabetic rats were administered orally with Ammania baccifera Linn leaf methanolic extract and isolated fraction (AB) at the dose of 250, 500mg/kg b.w. and 25, 50mg/kg b.w. and glibenclamide (600µg/kg b.w.) as standard by oral route for 45 days. Results: Methanolic extracts of Ammania baccifera Linn leaf, its isolated fraction AB and glibenclamide treated diabetic rats showed moderate reduction in blood glucose and glycosylated hemoglobin levels; in addition, plasma insulin and hemoglobin levels were elevated. Results of AB, Methanolic extract of Ammania baccifera Linn leaf were comparable to the standard drug glibenclamide (600µg/kg b.w). Conclusion: The present findings support the usage of the plant extracts for the treatment of diabetes and isolated fraction AB exhibited anti-hyperglycemic activity when compared with standard hypoglycemic agent.
KEYWORDS:
Diabetes, Ammania baccifera, glibenclamide, strptozotocin, AB.
Cite:
B. D. Patel, M. L. Kori. Antidiabetic Effect of Ammania baccifera Linn leaf on Streptozotocin Induced Diabetes in Male Albino Wistar Rats. Research J. Pharm. and Tech 2018; 11(11): 4773-4780.
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