Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  10

Year :  2018

Pages :   4317-4323

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synergistic Molecular Effect of BDNF, ApoE and MTHFR in inducing Depression in Alzheimer’s Disease



Address:   Zainab Mir1, Rosliza2, Behroz Naeem1, Ilyas Muhammad Nadeem2, Prof. Nordin Bin Simbak2, Prof. Zubaidi ALA2, Prof. Tengku Mohammad Ariff3, Khalili MR4, Mohammad Amjad Kamal5, Atif Amin Baig2*
1Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan.
2Faculty of Medicine, Universiti Sultan Zainal Abidin.
3iCode-Universiti Sultan Zainal Abidin.
4Faculty of Health Sciences, Univeristi Sultan Zainal Abidin.
5King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00790.4

ABSTRACT:
Alzheimer’s disease is genetically and pathophysiologically linked to depression. Various studies have been formulated on AD patients with depression and AD patients without depression. Genes like BDNF, ApoE and MTHFR have a significant role in depressed individuals causing the development of Alzheimer’s disease. The frequency of each gene marks the onset of Alzheimer’s disease. Single Nucleotide Polymorphisms in each specific gene show the increased risks of developing Alzheimer’s disease in depressed individuals. Amyloid Senile plaques and neurofibrillary tangles are caused more often in a depressed individual leading to AD. Development of antidepressants may lead to the correction and diminishing of AD in depressed individuals.
KEYWORDS:
Alzheimer’s Disease, Depression, BDNF gene, ApoE gene, MTHFR gene, Antidepressants.
Cite:
Zainab Mir1, Rosliza2, Behroz Naeem1, Ilyas Muhammad Nadeem2, Prof. Nordin Bin Simbak, Prof. Zubaidi ALA, Prof. Tengku Mohammad Ariff, Khalili MR, Mohammad Amjad Kamal, Atif Amin Baig. Synergistic Molecular Effect of BDNF, ApoE and MTHFR in inducing Depression in Alzheimer’s Disease. Research J. Pharm. and Tech 2018; 11(10): 4317-4323.
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