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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   01-08

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Buccal Tablets of Diclofenac Sodium using Semi-Synthetic Polymers



Address:   Venkatalakshmi Ranganathan*, Tan Siew Hui, Prasanthi Sri
Faculty of Pharmacy, Department of Dosage Form Design, MASHA University- Jalan SP 2,
Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia
*Corresponding Author
DOI No: 10.5958/0974-360X.2018.00001.X

ABSTRACT:
The purpose of this research work is to formulate and evaluate diclofenac sodium buccal tablets using semi-synthetic polymers such as hydroxypropyl methyl cellulose K4M (HPMC K4M), methyl cellulose (MC) and sodium carboxyl methyl cellulose (SCMC) along with ethyl cellulose (EC) as the backing membrane. The drug excipient compatibility study was carried out by Fourier transform infrared spectroscopy. The diclofenac sodium buccal tablets were formulated by direct compression method. The prepared diclofenac sodium buccal tablet were evaluated for general appearance, hardness, weight variation, thickness, swelling studies, drug content, friability test, in vitro disintegration test, in vitro dissolution test, in vitro drug release kinetic and ex vivo residence time.
KEYWORDS:
Diclofenac sodium, buccal tablet, semi-synthetic polymers, direct compression, ex vivo residence time.
Cite:
Venkatalakshmi Ranganathan, Tan Siew Hui, Prasanthi Sri. Formulation and Evaluation of Buccal Tablets of Diclofenac Sodium using Semi-Synthetic Polymers. Research J. Pharm. and Tech. 2018; 11(1): 01-08.
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