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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  8

Year :  2017

Pages :   2479-2486

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Royal Jelly against Carbon Tetrachloride (CCl4) Induced Toxicity in Male Rats.



Address:   AfyaaSabah Nasir1, Haider Salih Jaffat2
1Department of Ecology, Faculty of science, University of Kufa, Najaf, Iraq.
2Department of Biology, Faculty of science, University of Kufa, Najaf, Iraq.
*CorrespondingAuthor
DOI No: 10.5958/0974-360X.2017.00438.3

ABSTRACT:
The aim of this study was to investigate the ability of royal jelly in protecting rat testes against carbon tetrachloride induced testicular damage in male Wistar rats. Thirty six rats (weighting 220-235 g) were divided into six groups. The first group administrated distilled water and basal diet and kept as negative control, the second group administrated CCl4 as in equal volume with olive oil (1/1) and kept as negative control, the third group and fourth group were administrated royal jelly at two doses 150 mg/kg and 300 mg/kg , the fifthgroup and In sixth group were administrated CCl4 with royal jelly at two doses doses 150 mg/kg and 300 mg/kg respectively. At the end of experiment (50 days) the results show significant decrease in the sperm concentration, sperm viability, sperm motility in test sand significant increase in the sperm abnormality in the group of rats treated with CCl4 only while the results appear significant increase in sperm concentration, sperm viability, sperm motility in testes and significant decrease in the sperm abnormality in the groups of rats treated with CCl4and royal jelly at two doses respectively but all the sperm parameters like negative control in the group of rats treated with royal jelly at two doses only in compare with negative control. As well as the study demonstrated a significant decrease in sex hormones levels (T, LH,FSH)in the group of rats treated with CCl4 only while the results appear significant increase in the levels of six hormones in the group of rats treated with CCl4 and royal jelly at two doses respectively but all the levels of six hormones as negative control in the groups of rats treated with royal jelly at two doses only in compare with negative control.The histological in testes show complete swallowing of seminiferous tubules with degenerated germ cells and hypoplasia of Leydig cellsbut showing mild degeneration in spermatogenic cells and moderate degeneration of leydig cells in the groups of rats treated with CCl4 and royal also the histological results show normal seminiferous tubules with complete spermatogenic cells in the groups of rats treated with royal jelly only at two doses only. In conclusion, royal jelly is nonviolent and active in the treatment of infertility problem in male
KEYWORDS:
Sterility, Royal jelly and CCl4.
Cite:
AfyaaSabah Nasir, Haider Salih Jaffat. Effect of Royal Jelly against Carbon Tetrachloride (CCl4) Induced Toxicity in Male Rats. Research J. Pharm. and Tech. 2017; 10(8): 2479-2486.
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