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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  8

Year :  2017

Pages :   2446-2450

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Molecular Docking and In-vitro anti-inflammatory evaluation of Novel Isochromen-1-one analogues from Etodolac



Address:   Ayyakannu Arumugam Napoleon*, Vijay Sharma
Pharmaceutical Chemistry Laboratory, SAS, VIT University, Vellore - 632014, Tamil Nadu, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00432.2

ABSTRACT:
In the present work, the three synthesized isochromen-1-one, their thio and N-methylated analogues derived from the anti-inflammatory drug Etodolac are assessed for its in-vitro anti-inflammatory activity and carried out molecular docking studies. Docking study result shows that compound,5 possess good binding affinity with the COX-1 receptor showing a docking score of -8.2 and lipophilic interaction of -2.5 which is greater when compared to standard drugs such as Etodolac, Aceclofenac and Diclofenac were used. The same compound 5 also shows comparable in-vitro anti-inflammatory activity with etodolac as standard in both the methods screened.
KEYWORDS:
Molecular docking, Isochromen-1-one, Etodolac, Isochromen-1-one analogues, Anti-inflammatory activity.
Cite:
Ayyakannu Arumugam Napoleon, Vijay Sharma. Molecular Docking and In-vitro anti-inflammatory evaluation of Novel Isochromen-1-one analogues from Etodolac. Research J. Pharm. and Tech. 2017; 10(8): 2446-2450.
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