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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   687-692

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague –Dawley Rat Model



Address:   R. Suresh1, Dr. D. Benitojohnson2, Dr. C. Maheswari3, Dr. R. Venkatnarayanan4, Dr R.Manavalan5
1Professor, Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402
2Professor and Head, Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402
3Asst. Professor, Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402
4Principal, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402
5Head and Research Coordinator, Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00128.7

ABSTRACT:
The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-ß estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinoma
KEYWORDS:
Mammary carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.
Cite:
R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan. Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague –Dawley Rat Model. Research J. Pharm. and Tech. 2017; 10(3): 687-692.
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