List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Volume No. :   10

Issue No. :  3

Year :  2017

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Characterization of Indolyl-pyrazoline and their Evaluation of anti-inflammatory Activity



Address:   Minakshi Shroff1, Dr. S. J. Daharwal2, Yashwant Swarnakar3
1Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun. (U.K.)
2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)
3Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai (C.G.)
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00126.3

ABSTRACT:
In the present work, ten novel 3-(4,5-dihydro-3-(naphthalen-1-yl)- N1-substituted -pyrazol-5-yl)-1H-indole [1,1a,1b.1e,2] and 3-(4,5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5,5a,5b,5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenan-induced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.
KEYWORDS:
Anti-inflammatory activity, Carageenan induced paw oedema method, indole, pyrazoline, indolyl pyrazoline.
Cite:
Minakshi Shroff, S. J. Daharwal, Yashwant Swarnakar. Synthesis and Characterization of Indolyl-pyrazoline and their Evaluation of anti-inflammatory Activity. Research J. Pharm. and Tech. 2017; 10(3): 677-682.
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