List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   785-788

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Standardization of Extrusion Parameters during Liposomal Oxaliplatin Creation



Address:   Stadnichenko A.V.2, Krasnopolsky Y.M.1, Yarnykh T.G.2
1National Technical University Kharkiv Polytechnic Institute, Ukraine, 61000, Kharkov, Kirpichova St. 21.
2National University of Pharmacy, Ukraine, 61002, Kharkov, Pushkinskaya St. 53.
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00147.0

ABSTRACT:
The articl is dedicated to development of anticancer drug oxaliplatin in liposomal form. The drug is prospective from point of view of use in clinical practice as a form of low-toxic cytostatic drug for anticancer therapy. The principles for development of the lipid particles and impotence of their size for the formulation with high level of encapsulation is discussed. Parameters of high pressure homogenization techniques were researched. Method was standardized in field of the process parameters. Finished product was characterized by following parameters: size of the liposomes, encapsulation degree and zeta potential.
KEYWORDS:
Oxaliplatin liposomes, phosphatidylcholine, a lipid bilayer, homogenisation, extrusion under high pressure.
Cite:
Stadnichenko A.V., Krasnopolsky Y.M., Yarnykh T.G.. Standardization of Extrusion Parameters during Liposomal Oxaliplatin Creation. Research J. Pharm. and Tech. 2017; 10(3): 785-788.
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