Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   747-750

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent

Address:   Srinivasa Sastry D1, Narayana Charyulu R2, Satyanarayana D S, Srilakshmi D
1Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, India.
2Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00140.8

In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.
Omeprazole, Orodispersible tablets, Superdisintegrants.
Srinivasa Sastry D, Narayana Charyulu R, Satyanarayana D S, Srilakshmi D. Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent. Research J. Pharm. and Tech. 2017; 10(3): 747-750.
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