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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   739-742

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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New Analytical Techniques for the Determination of Epalrestat in Pharmaceutical Dosage forms by Spectrophotometry



Address:   Mukthinuthalapati Mathrusri Annapurna*, Malineni Sushmitha , Kunala Anusha
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00138.X

ABSTRACT:
Epalrestat is an aldose reductase inhibitor. Three simple, precise and accurate Spectrophotometric methods have been developed for the determination of Epalrestat in pharmaceutical formulations. Spectrophotometric analysis was performed and linearity was observed over the concentration range 0.1-25, 0.5-20 and 0.5-20 µg/ml in phosphate buffer (pH 5.0), phosphate buffer (pH 7.0) and borate buffer (pH 9.0) respectively. All the three methods were validated and can be used for the determination of Epalrestat in pharmaceutical formulations (Tablets).
KEYWORDS:
Epalrestat, phosphate buffer and borate buffer, Spectrophotometry, Validation.
Cite:
Mukthinuthalapati Mathrusri Annapurna, Malineni Sushmitha , Kunala Anusha. New Analytical Techniques for the Determination of Epalrestat in Pharmaceutical Dosage forms by Spectrophotometry. Research J. Pharm. and Tech. 2017; 10(3): 739-742.
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