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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  12

Year :  2017

Pages :   4133-4136

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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The Development of Industrial Technology of the Ointment Codenamed “Alergolik”



Address:   Rukhmakova O. A., Yarnykh T. G., Kovalenko S. N.
National University of Pharmacy, Ukraine, 61002, Kharkov, Pushkinskaya Str. 53.
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00752.1

ABSTRACT:
The article is dedicated to development of industrial technology of the ointment codenamed “Alergolik”. To study the uniformity of distribution of medicinal substances and excipients in the drug the optimal time of the ointment’s homogenization was found. The experiments showed that the ointment reaches homogeneity when it is stirring at 30 vol./min. by the frame stirrer during (20±2.5) min. Further stirring is impractical. Based on the complex of held biopharmaceutical, rheological and thermo gravimetric researches the rational technology of the ointment’s preparation in industrial conditions was developed. The critical parameters in the process of production (mixing duration - (20±2.5) min., temperature of preparation - (50.0±5.0)°C, mixer mode - 30 vol./min.) were set.
KEYWORDS:
Dermatitis, ointment, research, industrial technology, critical parameters.
Cite:
Rukhmakova O. A., Yarnykh T. G., Kovalenko S. N. The Development of Industrial Technology of the Ointment Codenamed “Alergolik”. Research J. Pharm. and Tech 2017; 10(12): 4133-4136.
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