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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  11

Year :  2017

Pages :   3877-3880

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Docking of HIV-1 with Neem using Autodock in Bioinformatics



Address:   R. Kannadasan1*, I. Arnold Emerson2, M. S. Saleem Basha3
1School of Computer Science and Engineering, VIT University, Vellore-632014, India
2School of Bioscience and Technology, VIT University, Vellore-632014, India
3Department of Computer Science, Mazoon University College, Muscat, Sultanate of Oman
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00704.1

ABSTRACT:
Protein is a chain amino acid each connected to its neighbor through a covalent peptide bond, therefore proteins are also known as polypeptides. HIV-1 disease is intellectual weakness which can go in seriousness from a mellow subclinical subjective wastefulness to an extreme twisting ailment. Human Immunodeficiency Virus (HIV) taints the cells of the insusceptible framework. Specifically, HIV assaults and pulverizes the T partner lymphocytes, or T-cells, which are essential to the insusceptible framework and invulnerable reaction. Docking enables us to understand the molecular interaction which take place between a ligand and a contrasting protein. The molecular docking can be done by an open source program which is the Auto Dock, It is developed to mimic and foresee how a drug and a ligand of known structure bind. This is used to find the binding energy and the inhibition constant. This information can be used to synthesize drugs for HIV-1.
KEYWORDS:
HIV-1, Neem, Auto dock..
Cite:
R. Kannadasan, I. Arnold Emerson, M. S. Saleem Basha. Docking of HIV-1 with Neem using Autodock in Bioinformatics. Research J. Pharm. and Tech 2017; 10(11): 3877-3880.
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