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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  11

Year :  2017

Pages :   3768-3774

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design, Synthesis and Characterization of 2-pyridone Derivatives as C-Jun N-terminal Kinases (JNKs) Signaling Pathway Inhibitors



Address:   Prem Shankar Mishra1, M. Vijey Aanandhi2*, V. Ravichandiran3
1Research Scholar, Department of Pharmaceutical Chemistry and Analysis, Vels University (VISTAS), Chennai- 600117. Tamilnadu, India.
2Department of Pharmaceutical Chemistry and Analysis, Vels University (VISTAS), Chennai- 600117. Tamilnadu, India.3NIPER, Kolkata, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00684.9

ABSTRACT:
A new series of 2-pyridone derivatives (A1-A6) were synthesized by various substitution and their structures were confirmed by spectral and elemental analyses. The cytotoxic activities of the newly synthesized compounds were docked against JNKs (2WAJ Transferase). JNKs pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. The molecular docking study was used for confirming their interaction with c-Jun N-terminal kinases (JNKs). Through in silico molecular docking study, the result showed that all synthesized derivatives (A1-A6) have low binding energy (Table 1) and have good affinity toward their active pocket thus the synthesized derivatives were considered as good JNKs inhibitors. This will help to inhibit the outgrowth of cell and can be act as good anti cancer agents.
KEYWORDS:
2-pyridone derivatives, JNKs signaling, Molecular docking methodology.
Cite:
Prem Shankar Mishra, M. Vijey Aanandhi, V. Ravichandiran. Design, Synthesis and Characterization of 2-pyridone Derivatives as C-Jun N-terminal Kinases (JNKs) Signaling Pathway Inhibitors. Research J. Pharm. and Tech 2017; 10(11): 3768-3774.
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