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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  10

Year :  2017

Pages :   3471-3473

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Study role of melatonin and leptin in patient infected with Entamoeba histolytica



Address:   Saleem Khteer Al-Hadraawy*
Department of Biology, College of Sciences, University of Kufa, Najaf, Iraq.
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00620.5

ABSTRACT:
The study was conducted on 60 patients infected with amoebiasis disease and 30 healthy male as control group whom have visited hospitals Laboratory in Al-Najaf Governorate during the period from November 2015 to May, 2016. It is designed to determine the effects of Entamoeba histolytica infection on some parameters such as melatonin, leptin, iron and Lactoferrin concentration. The results proved significant increased (P < 0.05) in serummelatonin concentration in patients with amoebiasis as compared to control group, while significant decrease (P < 0.05) in the serumleptin, iron and Lactoferrin levels in patients with amoebiasis as compared to the control group. CONCLUSIONS: The current study revealed high serum levels of melatonin in patients infected with E. histolytica, while low serum level of iron, Lactoferrin and leptin in patients with this parasite in compared with the control group. These results advocate a positive correlation between phagocytosis action and melatonin level in patients infected with E. histolytica parasite and the reason of decrease serum levels of leptin in patients infected with E. histolytica due to effects of early iron deficiency on the dopamine system and due to effects occur in receptor of leptin by this parasite.
KEYWORDS:
Melatonin, leptin, Najaf, iron, Entamoeba histolytica.
Cite:
Saleem Khteer Al-Hadraawy. Study role of melatonin and leptin in patient infected with Entamoeba histolytica. Research J. Pharm. and Tech 2017; 10(10):3471-3473.
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