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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   10

Issue No. :  10

Year :  2017

Pages :   3346-3352

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Eco-Friendly Synthesis, Characterization, Docking and Anti-Bacterial activity of Mannich Base Substituted Benzimidazoles



Address:   R. Pavithra, K. Hemalatha, Dr. K. Girija*
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Government of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06
*Corresponding Author
DOI No: 10.5958/0974-360X.2017.00595.9

ABSTRACT:
A series of some novel 1,2-disubstituted benzimidazole derivatives were synthesized by condensing 2-substituted benzimidazole with various primary amino compounds. The purity of synthesized compounds was confirmed by melting point determination and thin layer chromatography method. The chemical structure of synthesized compounds was characterized using IR-Spectroscopy. The compounds were docked against the target enzyme Biotin Carboxylase. The compounds showed significant binding energy (PA4, PA5, PA6, PA10) were evaluated for their in vitro anti-bacterial activity against Staphylococcus aureus and Salmonella typhi by well diffusion method using the standard drug Chloramphenicol. Among the tested compound PA 5 and PA6 shows significant anti-bacterial activity.
KEYWORDS:
2-Substituted Benzimidazoles, Biotin Carboxylase, Anti-bacterial activities, Staphylococcus aureus, Salmonella typhi..
Cite:
R. Pavithra, K. Hemalatha, K. Girija. Eco-Friendly Synthesis, Characterization, Docking and Anti-Bacterial activity of Mannich Base Substituted Benzimidazoles. Research J. Pharm. and Tech 2017; 10(10):3346-3352.
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