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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  7

Year :  2016

Pages :   1013-1016

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Significance of Jobs Plot in Cyclodextrin Complexation



Address:   Amber Vyas1, Bina Gidwani2, Atul Tripathi1, Preeti Dhruve1*
1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur
2Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00191.8

ABSTRACT:
Jobs plot or continuous variation method is used to estimate the stoichiometry in cyclodextrin complexation. Cyclodextrin complexation is well known as widely acceptable technique for improving the poor physic-chemical properties of BCS class II and class IV drugs. The stoichiometry of the inclusion complex is given by the number of guest and host molecules present in the supramolecular complex/inclusion system. The most common stoichiometry is 1:1, implying the inclusion of a single guest molecule. Now-a-days jobs plot is replaced by phase-solubility study. Jobs plot deals with spectral methods mainly for molecular modelling study of drugs and bioactives.
KEYWORDS:
cyclodextrin, complexation, jobs plot, phase solubility study
Cite:
Amber Vyas, Bina Gidwani, Atul Tripathi, Preeti Dhruve. Significance of Jobs Plot in Cyclodextrin Complexation. Research J. Pharm. and Tech. 2016; 9(7):1013-1016.
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