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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  5

Year :  2016

Pages :   625-632

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Nanosuspension Technologies for Delivery of Poorly Soluble Drugs- A Review



Address:   Harshil M. Patel1*, Bhumi B. Patel1, Dr. Chainesh N. Shah2, Dr, Dhiren P. Shah3
1M. Pharm, Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
2Assistant Professor, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
3Principal, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00120.7

ABSTRACT:
Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportion of newly discovered drugs are water insoluble and therefore poorly bioavailable contributing to desert development effort. Nanosuspensions have emerged as a promising strategy for the efficicent delivery of hydrophilic drugs because of their versatile features andunique advantages. The reduction of drug particles into submicron range leads to a significant increase in dissolution rate and therefore enhances bioavailability. Nanosuspension contain submicron colloidal dispersion of the pharmaceutical active ingredient particles in a liquid phase stabilised by surfactant. Nanosuspensions can be delivered by oral and non-oral route of administration. Study is focused on various methods of preparation with advantages and disadvantages, characterization properties, applications.
KEYWORDS:
Nanosuspension, solubility Enhancement, Bioavailability, Enhancement of dissolution, Hydrophilic drug.
Cite:
Harshil M. Patel, Bhumi B. Patel, Chainesh N. Shah, Dhiren P. Shah. Nanosuspension Technologies for Delivery of Poorly Soluble Drugs- A Review. Research J. Pharm. and Tech. 2016; 9(5): 625-632.
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