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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  5

Year :  2016

Pages :   538-540

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug

Address:   Pankaj Kumar*, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Science, NITTE University, Deralakatte, Mangalore-575018, Karnataka, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00101.3

Tenofovir Alafenamide is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. A simple, economical and accurate UV spectroscopy method was developed for Tenofoviral Afenamide in methanol and distill water in the ratio 20:80. It obeyed Beer’s law in the linearity range of 10 -50 µg/ml at an absorption maxima of 267 nm. The results are reproducible with coefficient of variance less than 1%. The linear regression of absorbance on concentration with coefficient of regression of almost 1 indicates a good linearity between absorbance and concentration. The value of percentage relative standard deviation of less than 1% and low range of percentage error shows high degree precision and accuracy of the method.
Tenofovir Alafenamide, reverse transcriptase, tenofovir, HIV infection, UV spectroscopy.
Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima. Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug. Research J. Pharm. and Tech. 2016; 9(5): 538-540.
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