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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  5

Year :  2016

Pages :   538-540

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug



Address:   Pankaj Kumar*, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Science, NITTE University, Deralakatte, Mangalore-575018, Karnataka, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00101.3

ABSTRACT:
Tenofovir Alafenamide is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. A simple, economical and accurate UV spectroscopy method was developed for Tenofoviral Afenamide in methanol and distill water in the ratio 20:80. It obeyed Beer’s law in the linearity range of 10 -50 µg/ml at an absorption maxima of 267 nm. The results are reproducible with coefficient of variance less than 1%. The linear regression of absorbance on concentration with coefficient of regression of almost 1 indicates a good linearity between absorbance and concentration. The value of percentage relative standard deviation of less than 1% and low range of percentage error shows high degree precision and accuracy of the method.
KEYWORDS:
Tenofovir Alafenamide, reverse transcriptase, tenofovir, HIV infection, UV spectroscopy.
Cite:
Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima. Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug. Research J. Pharm. and Tech. 2016; 9(5): 538-540.
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